

The Zebra ZD421d is a 4-inch advanced desktop label printer for shipping, product, asset, pharmacy and healthcare labels – the successor to Zebra's popular GK and ZD420 printers. As a direct thermal model it needs no ribbon – ideal for shipping labels, receipts and short-life labels. It prints sharp 300 dpi labels up to 108 mm wide at up to 102 mm/s, supports both ZPL and EPL and is managed with Zebra Print DNA and Link-OS. This version, ZD4A043-D0EM00EZ, connects via USB and USB Host, with Bluetooth Low Energy for quick setup from the Zebra Printer Setup app – Ethernet, serial or Wi-Fi can be added later with field-installable modules; the power supply, EU and UK power cords and a USB cable are included, so it is ready to print as soon as you add labels.
📦 What's in the box – ZD4A043-D0EM00EZ
- ✅ Zebra ZD421d printer – Grey, USB, BLE
- ✅ Power supply – 60 W external power supply (105934-053), 100–240 V
- ✅ Power cords – EU (Schuko) and UK (type G) plugs – use the one for your country
- ✅ USB cable – USB A to B, for connecting to your PC
- ✅ Setup guide – drivers, ZebraDesigner Essentials and manuals are a free download from Zebra
- ❌ Labels – NOT included
✅ Ready to print out of the box – power supply, power cords and USB cable are included; you only need labels.
💡 Useful extras: matching Zebra labels (Zebra Z-Perform 1000D 102 × 152 mm or Zebra Z-Select 2000D 57 × 32 mm); a field-installable cutter or label dispenser (Zebra P1112640-030 or Zebra P1112640-031); a Wi-Fi + Bluetooth upgrade module (Zebra P1134555-017C (Wi-Fi 6) or Zebra P1112640-017C (Wi-Fi 5)); an Ethernet module (Zebra P1112640-015); the battery base with battery for cart-based printing (Zebra P1080383-601 + Zebra P1080383-603).
Interactive 3D Model
Drag to rotate, scroll or pinch to zoom. Official Zebra 3D viewer – open in full screen ↗
Key Features
- Direct thermal – no ribbon needed – the simplest way to print shipping labels, receipts, visitor badges and food labels: just load a roll of thermal labels and print.
- Easy to operate – five status icons and a three-button interface show at a glance what the printer needs; colour-coded touch points and the OpenACCESS clamshell design make media changes quick.
- Handles virtually any media – roll-fed or fanfold labels, tags and continuous receipt paper from 15 mm to 108 mm wide, with a movable black-mark sensor and a multi-position gap sensor.
- USB today, network tomorrow – USB and USB Host as standard; the free modular connectivity slot takes a field-installable Ethernet or serial module, and a Wi-Fi + Bluetooth module can be added on site.
- Fits into your existing fleet – supports ZPL II and EPL 2, emulates other printer languages with Print DNA Virtual Devices and runs your existing GK-series label formats unchanged.
- Secure and remotely manageable – Print DNA with PrintSecure and Printer Profile Manager Enterprise; 512 MB flash, 256 MB SDRAM, real-time clock and ENERGY STAR certification.
- Upgrade on site – field-installable cutter or label dispenser, connectivity modules, an attached battery base for cart-based printing and the ZKDU keyboard display for stand-alone use.
Ideal Applications
- Transport and logistics – shipping, receiving and packing labels
- Retail – shelf labels, price markdowns, return tags and food information labels
- Healthcare and pharmacy – prescription, lab and specimen, blood bag and patient record labels
- Light manufacturing – product, agency, work-in-process and inventory labels
- Government, services and hospitality – asset and record labels, tickets and service reminder labels
All ZD421 Versions
The highlighted row is the version you are currently viewing.
| Part Number | Print Method | Resolution | Connectivity | ||
|---|---|---|---|---|---|
| ZD4A042-D0EE00EZ | Direct thermal | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-D0EM00EZ | Direct thermal | 203 dpi | USB, BLE | Standard | View product |
| ZD4A042-D0EW02EZ | Direct thermal | 203 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A042-D0EX02EZ | Direct thermal | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-D0EE00EZ | Direct thermal | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-D0EM00EZ (this version) | Direct thermal | 300 dpi | USB, BLE | Standard | Viewing |
| ZD4A043-D0EW02EZ | Direct thermal | 300 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A043-D0EX02EZ | Direct thermal | 300 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A042-30EE00EZ | Thermal transfer | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-30EM00EZ | Thermal transfer | 203 dpi | USB, BLE | Standard | View product |
| ZD4A042-30EW02EZ | Thermal transfer | 203 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A042-30EX02EZ | Thermal transfer | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-30EE00EZ | Thermal transfer | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-30EM00EZ | Thermal transfer | 300 dpi | USB, BLE | Standard | View product |
| ZD4A043-30EW02EZ | Thermal transfer | 300 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A043-30EX02EZ | Thermal transfer | 300 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A042-C0EE00EZ | Ribbon cartridge | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-C0EM00EZ | Ribbon cartridge | 203 dpi | USB, BLE | Standard | View product |
| ZD4A042-C0EX02EZ | Ribbon cartridge | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-C0EE00EZ | Ribbon cartridge | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-C0EM00EZ | Ribbon cartridge | 300 dpi | USB, BLE | Standard | View product |
Technical Specifications
| Part Number | ZD4A043-D0EM00EZ |
|---|---|
| Model | Zebra ZD421d |
| Printer Type | 4-inch advanced desktop label printer – direct thermal (ZD400 Series) |
| Print Method | Direct thermal |
| Resolution | 300 dpi (12 dots/mm) |
| Print Speed | Up to 102 mm/s (4 in/s) |
| Max. Print Width | 108 mm |
| Media Width | 15 mm to 108 mm |
| Label Length | 6.4 mm to 991 mm |
| Roll Diameter | Max. 127 mm (5.0 in) outer diameter |
| Core Size | 12.7 mm (0.5 in) and 25.4 mm (1 in) standard; 38.1 / 50.8 / 76.2 mm with optional core adapters |
| Media Thickness | 0.08 mm to 0.19 mm |
| Media Type | Roll-fed or fanfold, die-cut or continuous labels with or without black mark, tag stock, continuous receipt paper |
| Sensors | Full-width movable reflective / black-mark sensor; multi-position transmissive / gap sensor |
| Interfaces | USB 2.0, USB Host; free modular connectivity slot for a field-installable Ethernet 10/100 or RS-232 serial (DB-9) module |
| Wireless | Bluetooth Low Energy 5 (for the Zebra Printer Setup app); optional field-installable Wi-Fi + Bluetooth module |
| NFC | Print Touch (NFC) tag – tap to pair and open help pages |
| Memory | 512 MB flash, 256 MB SDRAM (64 MB / 8 MB user available); real-time clock |
| Printer Languages | ZPL II, EPL 2, XML, ZBI, PDF Direct; Print DNA Virtual Devices emulation; Link-OS |
| Fonts / Character Sets | 16 resident expandable ZPL II bitmap fonts, 2 scalable ZPL fonts, 5 EPL2 fonts, native OpenType support, Unicode |
| Barcodes | 1D: Code 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A/E, EAN-8/13 (+2/+5), Plessey, Postnet, 2-of-5 variants, Logmars, MSI, Codabar, Planet; 2D: Codablock, PDF417, Code 49, Data Matrix, MaxiCode, QR Code, MicroPDF, Aztec |
| Display | 5 status icons, 3-button user interface (no LCD) |
| Media Handling | Tear-off standard; field-installable cutter or label dispenser (peeler with label-present sensor) |
| Options | Ethernet, serial and Wi-Fi + Bluetooth modules; attached battery base + 2750 mAh battery; attached power supply base; ZKDU keyboard display unit; core adapters |
| Drivers & Software | Zebra Print DNA (Printer Profile Manager Enterprise, PrintSecure, Virtual Devices), ZebraDesigner Essentials, Zebra Setup Utilities, Windows drivers, Zebra Printer Setup app (Android / iOS) |
| Power Supply | 60 W external power supply, 100–240 V AC, 50–60 Hz, PFC; ENERGY STAR; optional 2750 mAh battery |
| Dimensions (W × D × H) | 177.5 × 220.8 × 150.7 mm |
| Weight | 1.35 kg |
| Color | Grey |
| Operating Temperature | 4.4 °C to 41 °C |
| Storage Temperature | −40 °C to 60 °C |
| Humidity | 10–90% non-condensing (storage 5–95%) |
| Certifications | IEC 62368-1, EN 55032 Class B, EN 55035, EN 61000-3-2/-3-3, EN 300 328, EN 301 893, CE, ENERGY STAR, RoHS |
| Warranty | 24 months |
| In the Box | Zebra ZD421d printer (USB, USB Host, BLE; grey), 60 W power supply (105934-053), power cords EU + UK, USB cable, quick start guide – labels NOT included |
Which ZD421 should you choose? The ZD421d (direct thermal) needs no ribbon and is ideal for shipping and short-life labels; the ZD421t uses 74 m or 300 m ribbon rolls for durable labels at the lowest cost per label; the ZD421c loads Zebra ribbon cartridges in seconds. 203 dpi suits most barcodes and shipping labels, while 300 dpi gives crisper small text and tiny 2D codes. Then pick Ethernet, USB (upgradeable), Wi-Fi 5 or Wi-Fi 6 to match your network. Compare other models in our Desktop Label Printers collection or contact our team for volume pricing.
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