

The Zebra ZD421c is a 4-inch advanced desktop label printer for shipping, product, asset, pharmacy and healthcare labels – the successor to Zebra's popular GK and ZD420 printers. Its unique ribbon cartridge loads in seconds – one way, first time, every time – and a smart chip tells you when the ribbon needs replacing. It prints sharp 203 dpi labels up to 104 mm wide at up to 152 mm/s, supports both ZPL and EPL and is managed with Zebra Print DNA and Link-OS. This version, ZD4A042-C0EM00EZ, connects via USB and USB Host, with Bluetooth Low Energy for quick setup from the Zebra Printer Setup app – Ethernet, serial or Wi-Fi can be added later with field-installable modules; the power supply, EU and UK power cords and a USB cable are included, so it is ready to print as soon as you add labels and a Zebra ribbon cartridge.
📦 What's in the box – ZD4A042-C0EM00EZ
- ✅ Zebra ZD421c printer – Grey, USB, BLE
- ✅ Power supply – 75 W external power supply, 100–240 V
- ✅ Power cords – EU (Schuko) and UK (type G) plugs – use the one for your country
- ✅ USB cable – USB A to B, for connecting to your PC
- ✅ Setup guide – drivers, ZebraDesigner Essentials and manuals are a free download from Zebra
- ❌ Labels – NOT included
- ❌ Ribbon cartridge – NOT included
✅ Ready to print out of the box – power supply, power cords and USB cable are included; you only need labels and a Zebra ribbon cartridge.
💡 Useful extras: matching Zebra labels (Zebra Z-Select 2000T 102 × 64 mm or Zebra Z-Ultimate 3000T 76 × 51 mm); Zebra ribbon cartridges (Zebra 2300 (02300CT11007) or Zebra 3300 (03300CT11007)); a field-installable cutter or label dispenser (Zebra P1116110-025 or Zebra P1112640-233); a Wi-Fi + Bluetooth upgrade module (Zebra P1112640-239C); an Ethernet module (Zebra P1112640-015); the battery base with battery for cart-based printing (Zebra P1080383-600 + Zebra P1080383-603).
Interactive 3D Model
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Key Features
- Ribbon cartridge – changed in seconds – fool-proof one-way loading without threading, and a smart chip that tracks the remaining ribbon and warns you before it runs out.
- Easy to operate – five status icons and a three-button interface show at a glance what the printer needs; colour-coded touch points and the OpenACCESS clamshell design make media changes quick.
- Handles virtually any media – roll-fed or fanfold labels, tags and continuous receipt paper from 15 mm to 118 mm wide, with a movable black-mark sensor and a multi-position gap sensor.
- USB today, network tomorrow – USB and USB Host as standard; the free modular connectivity slot takes a field-installable Ethernet or serial module, and a Wi-Fi + Bluetooth module can be added on site.
- Fits into your existing fleet – supports ZPL II and EPL 2, emulates other printer languages with Print DNA Virtual Devices and runs your existing GK-series label formats unchanged.
- Secure and remotely manageable – Print DNA with PrintSecure and Printer Profile Manager Enterprise; 512 MB flash, 256 MB SDRAM, real-time clock and ENERGY STAR certification.
- Upgrade on site – field-installable cutter or label dispenser, connectivity modules, an attached battery base for cart-based printing and the ZKDU keyboard display for stand-alone use.
Ideal Applications
- Transport and logistics – shipping, receiving and packing labels
- Retail – shelf labels, price markdowns, return tags and food information labels
- Healthcare and pharmacy – prescription, lab and specimen, blood bag and patient record labels
- Light manufacturing – product, agency, work-in-process and inventory labels
- Government, services and hospitality – asset and record labels, tickets and service reminder labels
All ZD421 Versions
The highlighted row is the version you are currently viewing.
| Part Number | Print Method | Resolution | Connectivity | ||
|---|---|---|---|---|---|
| ZD4A042-D0EE00EZ | Direct thermal | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-D0EM00EZ | Direct thermal | 203 dpi | USB, BLE | Standard | View product |
| ZD4A042-D0EW02EZ | Direct thermal | 203 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A042-D0EX02EZ | Direct thermal | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-D0EE00EZ | Direct thermal | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-D0EM00EZ | Direct thermal | 300 dpi | USB, BLE | Standard | View product |
| ZD4A043-D0EW02EZ | Direct thermal | 300 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A043-D0EX02EZ | Direct thermal | 300 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A042-30EE00EZ | Thermal transfer | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-30EM00EZ | Thermal transfer | 203 dpi | USB, BLE | Standard | View product |
| ZD4A042-30EW02EZ | Thermal transfer | 203 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A042-30EX02EZ | Thermal transfer | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-30EE00EZ | Thermal transfer | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-30EM00EZ | Thermal transfer | 300 dpi | USB, BLE | Standard | View product |
| ZD4A043-30EW02EZ | Thermal transfer | 300 dpi | USB, Wi-Fi 5 + BT 4.1 | Standard | View product |
| ZD4A043-30EX02EZ | Thermal transfer | 300 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A042-C0EE00EZ | Ribbon cartridge | 203 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A042-C0EM00EZ (this version) | Ribbon cartridge | 203 dpi | USB, BLE | Standard | Viewing |
| ZD4A042-C0EX02EZ | Ribbon cartridge | 203 dpi | USB, Wi-Fi 6 + BT 5.3 | Standard | View product |
| ZD4A043-C0EE00EZ | Ribbon cartridge | 300 dpi | USB, Ethernet, BLE | Standard | View product |
| ZD4A043-C0EM00EZ | Ribbon cartridge | 300 dpi | USB, BLE | Standard | View product |
Technical Specifications
| Part Number | ZD4A042-C0EM00EZ |
|---|---|
| Model | Zebra ZD421c |
| Printer Type | 4-inch advanced desktop label printer – thermal transfer, ribbon cartridge (ZD400 Series) |
| Print Method | Thermal transfer (ribbon cartridge) and direct thermal |
| Resolution | 203 dpi (8 dots/mm) |
| Print Speed | Up to 152 mm/s (6 in/s) |
| Max. Print Width | 104 mm (cartridge models: 104 mm at 203 and 300 dpi) |
| Media Width | 15 mm to 118 mm |
| Label Length | 6.4 mm to 991 mm |
| Roll Diameter | Max. 127 mm (5.0 in) outer diameter |
| Core Size | 12.7 mm (0.5 in) and 25.4 mm (1 in) standard; 38.1 / 50.8 / 76.2 mm with optional core adapters |
| Media Thickness | 0.08 mm to 0.19 mm |
| Media Type | Roll-fed or fanfold, die-cut or continuous labels with or without black mark, tag stock, continuous receipt paper |
| Sensors | Full-width movable reflective / black-mark sensor; multi-position transmissive / gap sensor |
| Ribbon | Zebra ribbon cartridges only – 74 m, 109.2 mm wide, with smart chip (ribbon-low alerts); wax, wax/resin and resin grades |
| Interfaces | USB 2.0, USB Host; free modular connectivity slot for a field-installable Ethernet 10/100 or RS-232 serial (DB-9) module |
| Wireless | Bluetooth Low Energy 5 (for the Zebra Printer Setup app); optional field-installable Wi-Fi + Bluetooth module |
| NFC | Print Touch (NFC) tag – tap to pair and open help pages |
| Memory | 512 MB flash, 256 MB SDRAM (64 MB / 8 MB user available); real-time clock |
| Printer Languages | ZPL II, EPL 2, XML, ZBI, PDF Direct; Print DNA Virtual Devices emulation; Link-OS |
| Fonts / Character Sets | 16 resident expandable ZPL II bitmap fonts, 2 scalable ZPL fonts, 5 EPL2 fonts, native OpenType support, Unicode |
| Barcodes | 1D: Code 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A/E, EAN-8/13 (+2/+5), Plessey, Postnet, 2-of-5 variants, Logmars, MSI, Codabar, Planet; 2D: Codablock, PDF417, Code 49, Data Matrix, MaxiCode, QR Code, MicroPDF, Aztec |
| Display | 5 status icons, 3-button user interface (no LCD) |
| Media Handling | Tear-off standard; field-installable cutter or label dispenser (peeler with label-present sensor) |
| Options | Ethernet, serial and Wi-Fi + Bluetooth modules; attached battery base + 2750 mAh battery; attached power supply base; ZKDU keyboard display unit; core adapters |
| Drivers & Software | Zebra Print DNA (Printer Profile Manager Enterprise, PrintSecure, Virtual Devices), ZebraDesigner Essentials, Zebra Setup Utilities, Windows drivers, Zebra Printer Setup app (Android / iOS) |
| Power Supply | 75 W external power supply, 100–240 V AC, 50–60 Hz, PFC; ENERGY STAR; optional 2750 mAh battery |
| Dimensions (W × D × H) | 202 × 254 × 177 mm |
| Weight | 2.3 kg |
| Color | Grey |
| Operating Temperature | 4.4 °C to 41 °C |
| Storage Temperature | −40 °C to 60 °C |
| Humidity | 10–90% non-condensing (storage 5–95%) |
| Certifications | IEC 62368-1, EN 55032 Class B, EN 55035, EN 61000-3-2/-3-3, EN 300 328, EN 301 893, CE, ENERGY STAR, RoHS |
| Warranty | 24 months |
| In the Box | Zebra ZD421c printer (USB, USB Host, BLE; grey), 75 W power supply, power cords EU + UK, USB cable, quick start guide – labels and ribbon cartridge NOT included |
Which ZD421 should you choose? The ZD421d (direct thermal) needs no ribbon and is ideal for shipping and short-life labels; the ZD421t uses 74 m or 300 m ribbon rolls for durable labels at the lowest cost per label; the ZD421c loads Zebra ribbon cartridges in seconds. 203 dpi suits most barcodes and shipping labels, while 300 dpi gives crisper small text and tiny 2D codes. Then pick Ethernet, USB (upgradeable), Wi-Fi 5 or Wi-Fi 6 to match your network. Compare other models in our Desktop Label Printers collection or contact our team for volume pricing.
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